Figure 5

Schematic representation of the most significantly affected pathway: “Antigen presentation pathway. (a) MHC II expression in the ependyma, A1. Mock (IF + DIC, 20×), A2. Infected (IF + DIC, 20×). Magnified images (63×) showing ependyma during NCC without DIC (A3) and with DIC (A4). (b) Chemokine CCL12 (B1-B4) and CCL5 (B5-B6) expression in ependyma, B1. Mock (IF + DIC, 20×), B2. Infected (IF + DIC, 20×). Magnified images showing CCL12 expression near parasite (B3) and cellular distribution of CCL12 (B4, 63×), CCL5 expression in mock (B5, IF, 40×) and infected (B6, IF, 40×). (e = ependyma, CP = choroid plexus, P = parasite).