Table 1 List of the most up- and downregulated (−) genes in ependymal cells from M. corti-infected brain in comparison to mock-infected brain samples
From: Transcriptome analysis of the ependymal barrier during murine neurocysticercosis
Molecules | Fold change | Molecular function | Biological process |
|---|---|---|---|
ARG1 | 142.1 | Arginase activity | Arginine and proline metabolism; urea cycle and metabolism of amino groups |
CD74 | 126.8 | MHC class II protein binding | Antigen processing and presentation of exogenous peptide antigen via MHC class II |
CCL8 | 83.18 | Chemokine activity; heparin binding | Cell-cell signaling; chemotaxis |
SAA1 | 77.66 | G-protein coupled receptor binding | Acute-phase response; chemotaxis |
PSMB9 | 74.76 | Peptidase activity | Antigen processing and presentation; aprotein polyubiquitination |
HLA-C | 53.43 | Beta-2-microglobulin binding; MHC class I receptor activity | Antigen processing and presentation of peptide antigen via MHC class I |
SRGN | 53.19 | Collagen binding; protein binding | Apoptotic process; biomineral tissue development; blood coagulation; maintenance of granzyme B location in T cell secretory granule |
HLA-E | 39.98 | MHC class I receptor activity | Antigen processing and presentation of peptide antigen via MHC class I |
HLA-B | 36.35 | MHC class I receptor activity | Antigen processing and presentation of peptide antigen via MHC class I |
C3AR1 | 33.81 | Complement component C3a receptor activity; G-protein coupled receptor activity; | Chemotaxis; complement receptor-mediated signaling pathway |
ST18 | −23.92 | DNA binding | Regulation of transcription |
ONECUT2 | −20.08 | Sequence-specific DNA binding transcription factor activity | Cell fate commitment; cilium assembly; epithelial cell development |
CEP76 | −17.01 | Protein binding | Regulation of centriole replication |
TNNT3 | −11.99 | Actin binding; calcium- dependent ATPase activity | Muscle contraction; muscle filament sliding; regulation of ATPase activity |
AZI2 | −6.99 | TBK1/IKKi-binding | I-kappaB kinase/NF-kappaB cascade |
METTL2B | −6.85 | Methyltransferase activity; transferase activity | Methylation |
PCF11 | −6.8 | RNA 3'-end processing | Termination of RNA polymerase II transcription |
C20ORF24 | −6.67 | ND | ND |
ACBD3 | −6.37 | Fatty-acyl-CoA binding | Lipid biosynthetic process; steroid biosynthetic process; transport |
SFRS8 | −5.65 | RNA binding | Negative regulation of nuclear mRNA splicing, regulation of transcription |