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Figure 1 | Journal of Neuroinflammation

Figure 1

From: MicroRNA-124 as a novel treatment for persistent hyperalgesia

Figure 1

MicroRNA-124 and CCAAT-enhancer-binding protein (C/EBP)-α expression after intraplantar interleukin (IL)-1β in wild-type (WT) and LysM-G protein–coupled receptor kinase (GRK)2 +/− mice. Control WT and LysM-GRK2+/− mice received an intraplantar injection of 1 ng IL-1β. (A) Percentage decrease in heat withdrawal latency after the injection in control WT and LysM-GRK2+/− mice (n = 12). At baseline (n = 9) and 24 hours (n = 6) after IL-1β injection, lumbar (L2 to L5) spinal cord microglia were isolated to determine (B) miR-124 expression (normalized for small nucleolar (sno)RNA55) and (C) the lumbar and thoracic mRNA expression of C/EBP-α normalized for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and actin) in control WT (n = 6) and LysM-GRK2+/− (n = 6) mice. n = One sample contains isolated microglia from four mice. Data are expressed as means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.

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