Figure 7

Effect of miR-124 treatment on SNI-induced mechanical allodynia in WT mice. Spared nerve injury was performed on WT mice and mice were treated daily with 100 ng miR-124 or control miRNA intrathecally (n = 7 per group). Mechanical allodynia was monitored in (A) ipsi- and (B) contralateral paw and is depicted as force needed for 50% withdrawal determined in accordance with the up and down method. Arrows indicate miRNA injection. (C) Spontaneous locomotor activity in an open field was monitored at day three after SNI to control for a potential effect of miR-124 treatment on motor function. Data are expressed as mean ± SEM. *** P < 0.01.