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Figure 2 | Journal of Neuroinflammation

Figure 2

From: IFN-γ-induced increase in the mobility of MHC class II compartments in astrocytes depends on intermediate filaments

Figure 2

Alexa Fluor 546 -dextran labels late endosomes/lysosomes in WT and GFAP -/- Vim -/- mouse astrocytes. Fluorescence images of WT (a) and GFAP -/- Vim -/- (b) astrocytes labeled with dextran and immunostained with antibodies against LAMP1, a marker of late endosomes/lysosomes. Merged images (overlay) show that the majority of dextran puncta are colocalized with LAMP1 puncta. Lower panels (insets) show boxed regions at higher magnification. Scale bars: 10 μm, 2 μm (insets). Arrowheads point to typical structures expressing both signals. Note that the green signal corresponding to the membrane bound LAMP-1 signal encircles the luminal signal of red dextran.

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Journal of Neuroinflammation

ISSN: 1742-2094