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Figure 10 | Journal of Neuroinflammation

Figure 10

From: Transforming growth factor β1-induced astrocyte migration is mediated in part by activating 5-lipoxygenase and cysteinyl leukotriene receptor 1

Figure 10

Diagram showing the roles of TGF-β1 and 5-LOX/CysLT 1 R in induction of astrocyte migration. TGF-β1 activates 5-LOX to produce CysLTs; the latter activates CysLT1R. Meanwhile, it also up-regulates CysLT1R expression, which enhances the activity of CysLT1R. The activated CysLT1R mediates TGF-β1-induced astrocyte migration.

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Journal of Neuroinflammation

ISSN: 1742-2094