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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Constitutive activity of NF-kappa B in myeloid cells drives pathogenicity of monocytes and macrophages during autoimmune neuroinflammation

Figure 2

FACS phenotying of lysMCreIκBα fl/fl mice. (A) Analysis of spleen cells from naïve lysMCreIκBαfl/fl mice (n = 7) and wild-type mice (n = 8). Isotype controls are coloured in red, CD11b+ cell fractions are marked with a yellow box. (B) FACS analyses show a significantly increased number of spleen-derived CD11b positive monocytes and CD11b/Ly6c double positive cells in lysMCreIκBαfl/fl mice. Data are shown in per cent of total cell count. (C) lysMCreIκBαfl/fl mice display a non significant increase of the co-stimulatory molecules CD80 and CD86. While there is no effect on MHC-II (C), there is a significant increase in Ly6c expression on CD11b+ cells from lysMCreIκBαfl/fl mice (D).

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