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Table 1 Overview of the experimental animals used in this study

From: Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice

Strain Genotype Animals, n Treatment   Time of tissue collection (use) Experiment
Prenatal Adult
129/C57Bl/6 Non-Tg 4 NaCI, 4 PolyI:C 4 months 15 months (IHC) Systemic infection in TgAD mice
3xTg-AD 5 NaCI, 7 PolyI:C 4 months 15 months (IHC)
C57Bl6/J Non-Tg 5 NaCI, 5 PolyI:C GD17 3 weeks (E) Prenatal infection in non-Tg mice: longitudinal changes in cytokine and brain APP/pTau levels and cognitive performance
4 NaCI, 4 PolyI:C GD17 3 months (IB/E)
5 NaCI, 5 PolyI:C GD17 5 months (E)
16 NaCI, 15 PolyI:C GD17 5 months (BT)
4 NaCI, 4 PolyI:C GD17 6 months (IB/E)
6 NaCI, 6 PolyI:C GD17 N* 12 months (IB)
4 NaCI, 5 PolyI:C GD17 15 months (IB/E)
6 NaCI, 6 PolyI:C GD17 15 months (IHC)
18 NaCI, 13 PolyI:C GD17 20 months (BT)
C57Bl6/J Non-Tg 6 NN*, 6 NP, 6N*, 7 PP GD17 9 months 12 months (IB) Prenatal and adult infection in non-Tg mice
10 NP, 11 PP GD17 12 months 15 months (IHC)
6 NN, 5 NP, 4 PN, 5 PP GD17 15 months 18 months (IHC)
  1. Abbreviations: APP, amyloid precursor protein; BT, behavioral testing; E, ELISA; GD, gestational day; IB, immunoblotting; IHC, immunohistochemistry; N = NaCI (0.9% saline); NN, prenatal and adult NaCI treatment; NP, prenatal NaCI and adult PolyI:C treatment; PN, prenatal PolyI:C and adult NaCI treatment; PP, prenatal and adult PolyI:C treatment; pTau, phosphorylated Tau.
  2. *Control group of first cohort used in experiment 3.