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Table 9 Changes (percent composition) in rat brain phosphatidylethanolamine molecular species following intraventricular infusion with propionic acid (PPA) and phosphate buffered saline (PBS)

From: The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders

Molecular weight

Molecular species

Plasmalogen or diacyl species

PBS

PPA

700

P34:1

p16:0/18:1

5.85 ± 0.15

5.10 ± 0.14*

714

D34:2

16:0/18:2

3.37 ± 0.17

3.49 ± 0.15

730

P36:0

p18:0/18:0

3.42 ± 0.13

4.03 ± 0.38

744

D36:1

18:0/18:1

3.50 ± 0.46

3.32 ± 0.37

728

P36:1

p18:0/18:1

6.00 ± 0.09

6.82 ± 0.12*

742

D36:2

18:0/18:2

3.68 ± 0.14

3.59 ± 0.35

726

P36:2

p18:0/18:2

4.79 ± 0.30

7.16 ± 0.62*

724

P36:3

p18:1/18:2

3.38 ± 0.42

2.98 ± 0.27

722

P36:4

p16:0/20:4

4.32 ± 0.12

4.43 ± 0.14

766

D38:4

18:0/20:4

6.99 ± 0.71

7.33 ± 0.62

750

P38:4

p18:0/20:4

6.07 ± 0.13

7.70 ± 0.02*

762

D38:6

16:0/22:6

4.18 ± 0.16

3.45 ± 0.15*

746

P38:6

p16:0/22:6

5.14 ± 0.45

5.11 ± 0.80

796

D40:3

18:0/22:3

3.59 ± 0.26

3.52 ± 0.43

794

D40:4

20:0/20:4

3.51 ± 0.08

3.85 ± 0.42

778

P40:4

p18:0/22:4

3.46 ± 0.26

5.00 ± 0.10*

792

D40:5

18:0/22:5

4.30 ± 0.31

3.93 ± 0.41

776

P40:5

p18:0/22:5

3.91 ± 0.69

3.79 ± 0.60

790

D40:6

18:0/22:6

11.07 ± 1.06

8.59 ± 0.36*

774

P40:6

p18:0/22:6

9.47 ± 0.21

6.82 ± 0.86*

Total%

  

100

100

∑ Saturates

  

3.42 ± 0.12

4.02 ± 0.38

∑ Monounsat

  

15.32 ± 0.65

15.23 ± 0.92

∑ Polyunsat

  

81.23 ± 0.69

80.73 ± 0.55

∑ Plas

  

55.82 ± 1.63

58.93 ± 1.40

  1. Values (nanomole percent by weight composition) represent means ± standard errors. Means in the same row accompanied by asterisks are significantly different between treatments at LSD = 0.05, n = 12 per treatment group. D represents diacyl species and P represents plasmalogens species, p denotes a sn-1 vinyl ether (plasmalogen) linkage. Monounsat, monounsaturated fatty acids; PBS, phosphate buffered saline solution; plas, plasmalogens; polyunsat, polyunsaturated fatty acids; PPA, propionic acid. Phosphatidylethanolamine molecular species were identified using a precursor ion scan of m/z 196 in ESI negative mode. The lipid components in the table are arranged based on the molecular species composition.