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Table 9 Changes (percent composition) in rat brain phosphatidylethanolamine molecular species following intraventricular infusion with propionic acid (PPA) and phosphate buffered saline (PBS)

From: The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders

Molecular weight Molecular species Plasmalogen or diacyl species PBS PPA
700 P34:1 p16:0/18:1 5.85 ± 0.15 5.10 ± 0.14*
714 D34:2 16:0/18:2 3.37 ± 0.17 3.49 ± 0.15
730 P36:0 p18:0/18:0 3.42 ± 0.13 4.03 ± 0.38
744 D36:1 18:0/18:1 3.50 ± 0.46 3.32 ± 0.37
728 P36:1 p18:0/18:1 6.00 ± 0.09 6.82 ± 0.12*
742 D36:2 18:0/18:2 3.68 ± 0.14 3.59 ± 0.35
726 P36:2 p18:0/18:2 4.79 ± 0.30 7.16 ± 0.62*
724 P36:3 p18:1/18:2 3.38 ± 0.42 2.98 ± 0.27
722 P36:4 p16:0/20:4 4.32 ± 0.12 4.43 ± 0.14
766 D38:4 18:0/20:4 6.99 ± 0.71 7.33 ± 0.62
750 P38:4 p18:0/20:4 6.07 ± 0.13 7.70 ± 0.02*
762 D38:6 16:0/22:6 4.18 ± 0.16 3.45 ± 0.15*
746 P38:6 p16:0/22:6 5.14 ± 0.45 5.11 ± 0.80
796 D40:3 18:0/22:3 3.59 ± 0.26 3.52 ± 0.43
794 D40:4 20:0/20:4 3.51 ± 0.08 3.85 ± 0.42
778 P40:4 p18:0/22:4 3.46 ± 0.26 5.00 ± 0.10*
792 D40:5 18:0/22:5 4.30 ± 0.31 3.93 ± 0.41
776 P40:5 p18:0/22:5 3.91 ± 0.69 3.79 ± 0.60
790 D40:6 18:0/22:6 11.07 ± 1.06 8.59 ± 0.36*
774 P40:6 p18:0/22:6 9.47 ± 0.21 6.82 ± 0.86*
Total%    100 100
∑ Saturates    3.42 ± 0.12 4.02 ± 0.38
∑ Monounsat    15.32 ± 0.65 15.23 ± 0.92
∑ Polyunsat    81.23 ± 0.69 80.73 ± 0.55
∑ Plas    55.82 ± 1.63 58.93 ± 1.40
  1. Values (nanomole percent by weight composition) represent means ± standard errors. Means in the same row accompanied by asterisks are significantly different between treatments at LSD = 0.05, n = 12 per treatment group. D represents diacyl species and P represents plasmalogens species, p denotes a sn-1 vinyl ether (plasmalogen) linkage. Monounsat, monounsaturated fatty acids; PBS, phosphate buffered saline solution; plas, plasmalogens; polyunsat, polyunsaturated fatty acids; PPA, propionic acid. Phosphatidylethanolamine molecular species were identified using a precursor ion scan of m/z 196 in ESI negative mode. The lipid components in the table are arranged based on the molecular species composition.