(A) Effect of des-Arg
-BK-induced thermal hyperalgesia in rats treated with capsaicin (1-50 mg/kg, s.c.) or vehicle, 24 h earlier. (B) Effect of the selective B1R antagonist (SSR240612, 10 mg/kg, p.o.) administered 3 h prior to des-Arg9-BK in capsaicin-treated rats (50 mg/kg, s.c.). (C) Effect of two TRPV1 antagonists (capsazepine 10 mg/kg, i.p. or 10 μg/site, i.t. and SB-366791 1 mg/kg, i.p. or 30 μg/site, i.t.) given 1h prior to capsaicin on thermal hyperalgesia induced by des-Arg9-BK and SP in capsaicin-treated rats (15 mg/kg, s.c.). Shown are the maximal hyperalgesic responses measured at 1 min post-injection of the agonist. Data represent the means ± S.E.M. of 5-7 rats per group. Comparison with the vehicle (*) is indicated by: * P < 0.05; ** P < 0.01; ***P < 0.001.