Time-course effect of des-Arg
-BK (9.6 nmol/site, i.t.) on thermal hyperalgesia in the tail-flick test from rats treated 24 h earlier with capsaicin (15 mg/kg, s.c.). Shown are the responses in rats housed under constant light (A) or a 12 h-12 h light-dark cycle (B). Data represent the means ± S.E.M. of 4 rats per group. Comparison with the 0 min group (*) is indicated by ** P < 0.01. No statistical significance was seen between the two groups.