Association of inflammatory gene polymorphisms with ischemic stroke in a Chinese Han population

Zhao, Nan; Liu, Xin; Wang, Yongqin; Liu, Xiaoqiu; Li, Jiana; Yu, Litian; Ma, Liyuan; Wang, Shuyu; Zhang, Hongye; Liu, Lisheng; Zhao, Jingbo; Wang, Xingyu

doi:10.1186/1742-2094-9-162

Journal of Neuroinflammation

Table 2 Association between single nucleotide polymorphisms (SNPs) and ischemic stroke

From: Association of inflammatory gene polymorphisms with ischemic stroke in a Chinese Han population

Gene	rsID	Minor allele	Risk allele	MAF, control:case	Additive model			FDR
Gene	rsID	Minor allele	Risk allele	MAF, control:case	OR	95% CI	Pvalue	FDR
CCL11	rs4795895	A	G	0.05:0.07	1.47	1.13 - 1.92	0.004	0.152
CCL11	rs3744508	A	A	0.14:0.12	1.2	1.01 -1.43	0.042	0.547
CCR5	rs1799987	A	A	0.46:0.43	1.13	1.00 - 1.27	0.051	0.547
TGFB1	rs1800469	C	C	0.48:0.49	0.9	0.80 - 1.11	0.071	0.547
NOS3	rs1799983	T	G	0.10:0.11	1.19	0.99 - 1.45	0.072	0.547
CCR2	rs1799864	A	A	0.27:0.25	1.11	0.97 - 1.27	0.143	0.614
IL6	rs1800796	G	G	0.33:0.31	1.1	0.97 - 1.25	0.144	0.614
IL4R	rs1801275	G	G	0.17:0.16	1.12	0.96 - 1.32	0.162	0.614
ADRB2	rs1042713	G	G	0.44:0.42	1.09	0.96 - 1.23	0.172	0.614
CD14	rs2569190	T	T	0.37:0.38	1.09	0.96 - 1.23	0.187	0.614
TNF	rs361525	A	A	0.05:0.05	1.2	0.90 - 1.61	0.208	0.614
FCERB1	rs569108	G	G	0.17:0.16	1.11	0.94 - 1.30	0.217	0.614
LTA	rs909253	G	G	0.42:0.41	1.08	0.95 - 1.22	0.227	0.614
IL1A	rs1800587	T	C	0.09:0.10	1.12	0.92 - 1.37	0.258	0.614
LTC4S	rs730012	C	C	0.15:0.14	1.1	0.93 - 1.30	0.263	0.614
ADRB2	rs1042714	G	G	0.07:0.11	1.11	0.92 - 1.34	0.267	0.614
VDR	rs2228570	T	T	0.45:0.43	1.15	0.89 - 1.49	0.282	0.614
IL10	rs1800872	C	A	0.35:0.36	1.07	0.95 - 1.21	0.291	0.614
GC	rs7041	G	G	0.27:0.26	1.07	0.94 - 1.23	0.321	0.642
VDR	rs1544410	A	A	0.06:0.05	1.05	0.94 - 1.19	0.387	0.735
IL5RA	rs2290608	A	A	0.24:0.23	1.06	0.92 - 1.22	0.435	0.787
IL1B	rs16944	T	T	0.49:0.47	1.05	0.93 - 1.18	0.456	0.788
TNF	rs1800629	A	A	0.06:0.06	1.09	0.86 - 1.39	0.478	0.79
CTLA4	rs5742909	T	C	0.13:0.14	1.06	0.89 - 1.26	0.528	0.81
CSF2	rs25882	T	C	0.38:0.39	1.04	0.92 - 1.17	0.533	0.81
TCF7	rs244656	T	A	0.12:0.13	1.04	0.87 - 1.25	0.649	0.856
IL4R	rs1805015	C	C	0.08:0.08	1.05	0.84 - 1.30	0.669	0.856
SELP	rs6131	A	A	0.19:0.20	1.03	0.89 - 1.20	0.674	0.856
IL13	rs1295686	T	C	0.28:0.29	1.03	0.90 - 1.17	0.679	0.856
VCAM1	rs1041163	C	T	0.15:0.16	1.03	0.88 - 1.21	0.687	0.856
CXCL12	rs1801157	A	G	0.21:0.22	1.03	0.89 - 1.19	0.698	0.856
CTLA4	rs231775	A	G	0.31:0.31	1.02	0.90 - 1.16	0.738	0.876
C5	rs17611	G	G	0.42:0.42	1.02	0.90 - 1.15	0.768	0.884
IL4R	rs1805010	G	G	0.48:0.48	1.01	0.90 - 1.14	0.827	0.899
ICAM1	rs5491	T	T	0.07:0.06	1.03	0.80 - 1.31	0.828	0.899
UGB	rs3741240	A	A	0.43:0.43	1.03	0.89 - 1.13	0.965	0.977
NOS2A	rs1137933	T	T	0.13:0.13	1.00	0.84 - 1.19	0.97	0.977
GC	rs4588	A	A	0.32:0.32	1.00	0.88 - 1.14	0.977	0.977

OR was calculated using a reference allele that resulted in an OR >1. P value and FDR adjusted for age, sex, body mass index and hypertension status in additive model of inheritance.
FDR = false discovery rate; MAF = minor allele frequency.

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ISSN: 1742-2094

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