Association of inflammatory gene polymorphisms with ischemic stroke in a Chinese Han population

Table 3 Single nucleotide polymorphisms (SNPs) achieving P <0.05 for association with ischemic stroke based on hypertension-stratified population

Gene	rsID	Minor allele	Risk allele	MAF, control:case	OR	95% CI	Pvalue	FDR
Non-hypertension
CCL11	rs4795895	A	G	0.07:0.05	1.57	1.05 - 2.66	0.032	0.202
CCL11	rs3744508	A	A	0.10:0.16	1.64	1.20 - 2.25	0.002	0.076
LTA	rs909253	G	G	0.39:0.45	1.29	1.03 - 1.60	0.024	0.182
LTC4S	rs730012	C	C	0.11:0.16	1.55	1.13 - 2.12	0.007	0.086
TGFB1	rs1800469	C	C	0.46:0.46	1.30	1.07 - 1.59	0.009	0.086
FCERB1	rs569108	G	G	0.12:0.17	1.49	1.11 - 2.00	0.009	0.086
Hypertension
CCL11	rs4795895	A	G	0.07:0.05	1.45	1.05 - 1.99	0.023	0.291
CCR2	rs1799864	A	A	0.23:0.28	1.26	1.06 - 1.49	0.008	0.152
CCR5	rs1799987	A	A	0.43:0.48	1.23	1.06 - 1.42	0.007	0.152

Non-hypertension: cases = 397 controls = 347; hypertension: cases = 727 controls = 816. OR was calculated using a reference allele that resulted in an OR >1. P value and FDR adjusted for age, sex and body mass index in additive model of inheritance.
FDR = false discovery rate; MAF = minor allele frequency.

ISSN: 1742-2094