Figure 3

Increased hippocampal neurogenesis in running mice four days after bacterial meningitis. Four days after infection, the density of TUC-4- (A, B) as well as doublecortin-expressing (C, D) young neurons was significantly increased in the granule cell layer of the dentate gyrus after voluntary wheel running in comparison to sedentary mice. (B) and (D) represent the median and interquartile range of the densities of immunoreactive cells (example in A und C)/mm² dentate gyrus, P = 0.012 and P = 0.015, respectively, Mann–Whitney U-test, scale bar = 50 μm).