Cell cycle inhibition by CR8 significantly improves functional recovery after SCI. Both BBB and CBS scores were evaluated 1 day post injury and weekly thereafter in drug- vs. vehicle-treated rats. Both BBB and CBS tests showed a significant beneficial effect of delayed systemic CR8 treatment on functional recovery. The effect of treatment was statistically significant beginning at week 2 as measured by BBB score and beginning at week 3 as measured by CBS score. Both measures showed significantly improved recovery chronically at 4–16 weeks after SCI. *p < 0.05 vs. vehicle group at indicated time point.