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Figure 9 | Journal of Neuroinflammation

Figure 9

From: P2X7 signaling promotes microsphere embolism-triggered microglia activation by maintaining elevation of Fas ligand

Figure 9

Microsphere embolism-induced FasL activation and the apoptosis cascade were inhibited by minocycline treatment in ME rats. (A) Neurological scores were determined 168 h after ME with or without minocycline treatment. Data are expressed as means ± SEM (n = 6 rats). *P <0.05 vs. vehicle-treated rats. (B) Immunoblots demonstrating FasL/Fas cell death signaling measured 168 h after ME with or without post-treatment with minocycline. Quantified data are shown in (C). Data are expressed as means ± SEM (n = 6 rats). *P <0.05; **P <0.01 vs. Sham; # P <0.05 vs. ME group. ME, microsphere embolism.

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