Figure 3

Th2 cytokines at baseline. (A) Abnormal elevations in levels of Th2 cytokines IL-6, IL-10 and IL-13 and (B) Th2-associated chemokines, RANTES (regulated upon activation, normal T-cell expressed, and secreted) and macrophage inflammatory protein 1α (MIP-1α), in MyD88^−/− mice at baseline and significant decreases in levels of these cytokines at the indicated time points following permanent middle cerebral artery occlusion (pMCAO) compared to wild type (WT). Interestingly, Th1-associated monocyte chemoattractant protein 1 significantly increased in the brains of MyD88^−/− mice 24 hours following pMCAO to when levels had started to decrease towards baseline in WT mice. *p < 0.05; MyD88^−/− or Toll/interleukin 1 receptor domain-containing adaptor-inducing interferon β-mutant compared to WT. N = 9 per group and n = 3 per time point. 0 hours = baseline.