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Table 1 MyD88-dependent cytokines/chemokines following permanent middle cerebral artery occlusion

From: Downstream Toll-like receptor signaling mediates adaptor-specific cytokine expression following focal cerebral ischemia

Location   WT   MyD88−/−   TRIF   p-value
Serum (pg/ml)         
IL-6 Baseline 24.7 ± 15.2   83.3 ± 69.5   30.9 ± 28.7   n.s.
  3 hours 205.2 ± 19.8 (↑8.3) 59.9 ± 3.9 (↓1.4) 130.9 ± 50.7 (↑4.2) 0.027,* <0.05
  24 hours 91.5 ± 12.6   37.3 ± 18.7   62.9. ± 21.0   <0.05
KC Baseline 88.5 ± 19.4   81.1 ± 12.3   70.3 ± 29.9   n.s.
  3 hours 758.8 ± 164.4 (↑8.6) 182.5 ± 47.9 (↑2.3) 595.1 ± 291.3 (↑8.5) <0.05
  24 hours 208.1 ± 52.6   81.3 ± 21.1   221.3 ± 103.3   <0.05
G-CSF Baseline 1,613.8 ± 939.8   185.7 ± 54.6   1,965.3 ± 1,626.3   <0.05
  3 hours 980.3 ± 424.0 (↓1.6) 154.3 ± 88.6 (↓1.2) 787.4 ± 61.5 (↓2.5) <0.05
  24 hours 1,566.7 ± 91.0   207.8 ± 133.8   1,282.7 ± 444.9   <0.05
Brain (pg/g/ml)         
IL-6 Baseline ND   ND   ND   
  3 hours 1,912.3 ± 2,665.9   182.3 ± 54.4   1,269.8 ± 1,643.7   <0.05
  24 hours 2,293.7 ± 1,986.5   1,811.9 ± 1,224.0   4,858.6 ± 5201.7   n.s.
KC Baseline 692.9 ± 461.5   108.2 ± 15.7   1,400.3 ± 879.4   0.030,* 0.034
  3 hours 3,271.3 ± 2,446.9 (↑4.7) 1,230.1 ± 426.6 (↑11.4) 2,405.8 ± 1,823.6 (↑1.7) <0.05
  24 hours 1,066.0 ± 760.4   1,080.3 ± 168.6   1,694.2 ± 836.7   n.s.
G-CSF Baseline 16.7 ± 14.4   3.3 ± 3.8   14.2 ± 7.7   n.s.
  3 hours 962.5 ± 1,272.7 (↑57.6) 57.8 ± 26.3 (↑17.5) 652.5 ± 749.6 (↑45.9) <0.05
  24 hours 3,458.4 ± 5,056.6   505.3 ± 480.5   4,610.8 ± 3,333.3   n.s.
IL-10 Baseline 91.3 ± 85.7   195.2 ± 204.9   510.9 ± 447.3   n.s.
  3 hours 1,047 ± 621.76 (↑11.5) 87 ± 55.25 (↓2.2) 319.1 ± 415.77 (↓1.6) <0.05
  1. G-CSF granulocyte colony-stimulating factor, IL interleukin, KC keratinocyte chemoattractant, ND not detectable, TRIF Toll/interleukin 1 receptor domain-containing adaptor-inducing interferon β, WT wild type.
  2. *Significantly different between all three groups using Kruskal-Wallis test.
  3. Significantly different between WT and MyD88 using Mann–Whitney test.
  4. Parentheses: Fold change compared to baseline for that particular group.