Table 1 MyD88-dependent cytokines/chemokines following permanent middle cerebral artery occlusion
Location | WT | MyD88−/− | TRIF | p-value | ||||
|---|---|---|---|---|---|---|---|---|
Serum (pg/ml) | ||||||||
IL-6 | Baseline | 24.7 ± 15.2 | 83.3 ± 69.5 | 30.9 ± 28.7 | n.s.† | |||
3 hours | 205.2 ± 19.8 | (↑8.3) | 59.9 ± 3.9 | (↓1.4) | 130.9 ± 50.7 | (↑4.2) | 0.027,* <0.05† | |
24 hours | 91.5 ± 12.6 | 37.3 ± 18.7 | 62.9. ± 21.0 | <0.05† | ||||
KC | Baseline | 88.5 ± 19.4 | 81.1 ± 12.3 | 70.3 ± 29.9 | n.s.† | |||
3 hours | 758.8 ± 164.4 | (↑8.6) | 182.5 ± 47.9 | (↑2.3) | 595.1 ± 291.3 | (↑8.5) | <0.05† | |
24 hours | 208.1 ± 52.6 | 81.3 ± 21.1 | 221.3 ± 103.3 | <0.05† | ||||
G-CSF | Baseline | 1,613.8 ± 939.8 | 185.7 ± 54.6 | 1,965.3 ± 1,626.3 | <0.05† | |||
3 hours | 980.3 ± 424.0 | (↓1.6) | 154.3 ± 88.6 | (↓1.2) | 787.4 ± 61.5 | (↓2.5) | <0.05† | |
24 hours | 1,566.7 ± 91.0 | 207.8 ± 133.8 | 1,282.7 ± 444.9 | <0.05† | ||||
Brain (pg/g/ml) | ||||||||
IL-6 | Baseline | ND | ND | ND | ||||
3 hours | 1,912.3 ± 2,665.9 | 182.3 ± 54.4 | 1,269.8 ± 1,643.7 | <0.05† | ||||
24 hours | 2,293.7 ± 1,986.5 | 1,811.9 ± 1,224.0 | 4,858.6 ± 5201.7 | n.s. | ||||
KC | Baseline | 692.9 ± 461.5 | 108.2 ± 15.7 | 1,400.3 ± 879.4 | 0.030,* 0.034† | |||
3 hours | 3,271.3 ± 2,446.9 | (↑4.7) | 1,230.1 ± 426.6 | (↑11.4) | 2,405.8 ± 1,823.6 | (↑1.7) | <0.05† | |
24 hours | 1,066.0 ± 760.4 | 1,080.3 ± 168.6 | 1,694.2 ± 836.7 | n.s. | ||||
G-CSF | Baseline | 16.7 ± 14.4 | 3.3 ± 3.8 | 14.2 ± 7.7 | n.s. | |||
3 hours | 962.5 ± 1,272.7 | (↑57.6) | 57.8 ± 26.3 | (↑17.5) | 652.5 ± 749.6 | (↑45.9) | <0.05† | |
24 hours | 3,458.4 ± 5,056.6 | 505.3 ± 480.5 | 4,610.8 ± 3,333.3 | n.s. | ||||
IL-10 | Baseline | 91.3 ± 85.7 | 195.2 ± 204.9 | 510.9 ± 447.3 | n.s. | |||
3 hours | 1,047 ± 621.76 | (↑11.5) | 87 ± 55.25 | (↓2.2) | 319.1 ± 415.77 | (↓1.6) | <0.05† |