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Table 2 TRIF-dependent cytokine/chemokines following permanent middle cerebral artery occlusion

From: Downstream Toll-like receptor signaling mediates adaptor-specific cytokine expression following focal cerebral ischemia

Location   WT MyD88−/− TRIF P-value
Serum (pg/ml)      
IP-10 Baseline 164.8 ± 25.1 124.1 ± 17.6 147.5 ± 35.9 n.s.
  3 hours 121.4 ± 11.4 105.9 ± 37.0 104.9 ± 18.9 n.s.
  24 hours 164.7 ± 9.1 135.8 ± 21.9 113.9 ± 16.7 <0.05
MIP-1α Baseline 169.3 ± 28.1 140.9 ± 153.9 41.7 ± 72.2 <0.05
  3 hours 166.4 ± 23.4 71.5 ± 62.7 100.4 ± 68.3 n.s.
  24 hours 145.7 ± 22.6 6.7 ± 11.6 30.9 ± 53.5 <0.05
Brain (pg/ml/g)      
IP-10 Baseline 1,095.9 ± 159.5 985.4 ± 207.7 619.2 ± 141.2 <0.05
  3 hours 2,077.2 ± 803.6 1087.5 ± 190.4 710.5 ± 223.0 0.039,* <0.05
  24 hours 2,997.3 ± 2,074.2 5169.9 ± 3305 2,820 ± 1,273 n.s.
MIP-1α Baseline 1,096.3 ± 372.6 1026.1 ± 434.6 228.2 ± 395.3 <0.05
  3 hours 1,267.8 ± 210.9 891.5 ± 501.6 171.2 ± 148.7 <0.05
  24 hours 1,088.2 ± 413.6 1293.9 ± 741.1 403.1 ± 355.7 n.s.
  1. IP-10 inducible protein 10, MIP-1α macrophage inflammatory protein 1α, TRIF Toll/interleukin 1 receptor domain-containing adaptor-inducing interferon β, WT wild type.
  2. *Significantly different between all three groups using Kruskal-Wallis.
  3. Significantly different between WT and TRIF mutant using Mann–Whitney test.
  4. Parentheses: fold change compared to baseline for that particular group.