c-Jun N-terminal kinase (JNK) antisense oligodeoxynucleotide significantly attenuated white matter injury. Antisense oligodeoxynucleotide (ODN) treatment (n = 8) markedly increased myelin basic protein (MBP) (A) and decreased glial fibrillary acidic protein (GFAP) (B) expression in the white matter compared with scrambled ODN (n = 8) on P11 after lipopolysaccharide (LPS)-sensitized hypoxic-ischemia (HI) on P2. Scale bar = 200 μm in (A), 100 μm in (B). Values are means ± SEM. ***P < 0.001, *P < 0.05.