Figure 3From: JNK signaling is the shared pathway linking neuroinflammation, blood–brain barrier disruption, and oligodendroglial apoptosis in the white matter injury of the immature brain JNK activation in microglia, vascular endothelial cells and oligodendrocyte progenitors at 6 h post-insult. Immunofluorescence of the ipsilateral white matter in the lipopolysaccharide (LPS) + hypoxic-ischemic (HI) group showed increased phospho-c-Jun N-terminal kinase (p-JNK) expression in (A) ED1-positive microglia, (B) RECA-positive endothelial cells and (C) O4-positive oligodendrocyte progenitors. Scale bar = 25 μm. Inset scale bar = 5 μm in (A), 10 μm in (B) and 2.5 μm in (C).Back to article page