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Figure 7 | Journal of Neuroinflammation

Figure 7

From: JNK signaling is the shared pathway linking neuroinflammation, blood–brain barrier disruption, and oligodendroglial apoptosis in the white matter injury of the immature brain

Figure 7

AS601245 significantly reduced perivascular attachment of p-JNK-positive cells and cell apoptosis in the white matter 24 h post-insult. Immunofluorescent staining in the lipopolysaccharide (LPS) + hypoxic-ischemic (HI) group showed that, compared with vehicle, AS601245 (40 mg/kg) significantly attenuated perivascular phospho-c-Jun N-terminal kinase (p-JNK)-positive cell attachment (A), and also decreased cleaved caspase 3-positive endothelial (B) and oligodendroglial cells (C) in the white matter. Scale bar =25 μm.

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Journal of Neuroinflammation

ISSN: 1742-2094