Pharmacological inhibition of c-Jun N-terminal kinase (JNK) activity using AS601245 significantly attenuated white matter injury. AS601245 (40 mg/kg) (n = 8) but not AS601245 (20 mg/kg) (n = 8) treatment had significantly higher myelin basic protein (MBP) (A) and lower glial fibrillary acidic protein (GFAP) (B) expression in the white matter than vehicle (n = 10) on P11 after lipopolysaccharide (LPS)-sensitized hypoxic-ischemia (HI) on P2. Scale bar = 200 μm in (A), 100 μm in (B). Values are means ± SEM. ***P < 0.001, **P < 0.01, *P < 0.05.