Figure 2

Peripheral nerve injury induces M2 associated genes. RT-qPCR analysis of the immune response up to 14 days post injury, showing macrophage markers (a), cytokine expression (b), M1 associated genes (c), and M2 associated markers (d). Sham operation induces M2 markers, but only to a minor extent compared to acute neurodegeneration (e). The mRNA levels are expressed relative to the basal condition (=0 h time point). Data presented are the compiled data of different independent experiments, with n representing the number of independent experiments for each gene. For sham operation one representative experiment out of two independent experiments is shown.