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Figure 4 | Journal of Neuroinflammation

Figure 4

From: C/EBPβ regulates multiple IL-1β-induced human astrocyte inflammatory genes

Figure 4

IL-1β signals through ERK1/2 and p38K to increase astrocyte BDKRB2 and COX-2 mRNA, respectively. Astrocytes were cultured for 24 h, pretreated with pathway-selective inhibitors (20 μM) and then treated with IL-1β for 12 h. Total RNA was isolated, reverse-transcribed and then assayed by RT2PCR for (A) BDKRB2 or (B) COX-2 relative transcript levels. GAPDH was used as the normalizing control; p-values are compared to control unless denoted by lines to specific comparisons.

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