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Table 1 Effects of fracture on trabecular and cortical bone parameters assessed by ex vivo μCT

From: Keratinocyte expression of inflammatory mediators plays a crucial role in substance P-induced acute and chronic pain

 

Control

Fracture ipsilateral

Fracture + LY ipsilateral

Fracture contralateral

Fracture + LY contralateral

Distal femur

 BV/TV (%)

12.5 ± 0.6

6.60 ± 1.22***

7.31 ± 0.72***

10.63 ± 1.27

11.13 ± 0.84*

 TbN (mm-1)

2.78 ± 0.08

2.38 ± 0.17

2.43 ± 0.14

2.91 ± 0.17

2.87 ± 0.15

 TbTh (μm)

65.3 ± 1.1

57.6 ± 2.2***

62.1 ± 1.2***

63.2 ± 2.2

66.5 ± 1.2

 TbSp (μm)

372 ± 11

441 ± 31

428 ± 25

358 ± 22

360 ± 18

 ConnD (1/mm3)

40.0 ± 2.7

14.0 ± 4.3***

14.7 ± 2.5**

29.5 ± 5.2*

29.4 ± 3.8*

Femur midshaft

 BAr (mm2)

7.36 ± 0.13

7.42 ± 0.13

7.34 ± 0.21

7.27 ± 0.14

7.34 ± 0.20

 TtAr (mm2)

13.4 ± 0.4

13.4 ± 0.3

13.1 ± 0.3

13.2 ± 0.3

13.1 ± 0.3

 MeAr (mm2)

6.11 ± 0.29

5.99 ± 0.22

5.74 ± 0.24

5.96 ± 0.21

5.72 ± 0.23

 CtTh (μm)

703 ± 6

720 ± 7

723 ± 18

707 ± 8

725 ± 20

 BPm (mm)

23.9 ± 0.5

22.4 ± 0.4*

21.3 ± 0.4**

22.6 ± 0.4

21.9 ± 0.3**

 BAr/TtAr (%)

54.8 ± 0.9

55.4 ± 0.7

56.2 ± 1.3

55.0 ± 0.5

56.2 ± 1.3

  1. Statistical significance determined from one-way analysis of variance (ANOVA) followed by post hoc Newman-Keuls test. All data are expressed as means ± standard error of the mean. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. controls.
  2. BV: bone volume; TV: total volume; TbN: trabecular number; TbTh: trabecular thickness; TbSp: trabecular separation; ConnD: connectivity density; Bar: bone area: TtAr: total cross sectional area; MeAr: medullary area; CtTh: cortical thickness; BPm: bone perimeter; LY: LY303870.