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Table 1 Effects of fracture on trabecular and cortical bone parameters assessed by ex vivo μCT

From: Keratinocyte expression of inflammatory mediators plays a crucial role in substance P-induced acute and chronic pain

  Control Fracture ipsilateral Fracture + LY ipsilateral Fracture contralateral Fracture + LY contralateral
Distal femur
 BV/TV (%) 12.5 ± 0.6 6.60 ± 1.22*** 7.31 ± 0.72*** 10.63 ± 1.27 11.13 ± 0.84*
 TbN (mm-1) 2.78 ± 0.08 2.38 ± 0.17 2.43 ± 0.14 2.91 ± 0.17 2.87 ± 0.15
 TbTh (μm) 65.3 ± 1.1 57.6 ± 2.2*** 62.1 ± 1.2*** 63.2 ± 2.2 66.5 ± 1.2
 TbSp (μm) 372 ± 11 441 ± 31 428 ± 25 358 ± 22 360 ± 18
 ConnD (1/mm3) 40.0 ± 2.7 14.0 ± 4.3*** 14.7 ± 2.5** 29.5 ± 5.2* 29.4 ± 3.8*
Femur midshaft
 BAr (mm2) 7.36 ± 0.13 7.42 ± 0.13 7.34 ± 0.21 7.27 ± 0.14 7.34 ± 0.20
 TtAr (mm2) 13.4 ± 0.4 13.4 ± 0.3 13.1 ± 0.3 13.2 ± 0.3 13.1 ± 0.3
 MeAr (mm2) 6.11 ± 0.29 5.99 ± 0.22 5.74 ± 0.24 5.96 ± 0.21 5.72 ± 0.23
 CtTh (μm) 703 ± 6 720 ± 7 723 ± 18 707 ± 8 725 ± 20
 BPm (mm) 23.9 ± 0.5 22.4 ± 0.4* 21.3 ± 0.4** 22.6 ± 0.4 21.9 ± 0.3**
 BAr/TtAr (%) 54.8 ± 0.9 55.4 ± 0.7 56.2 ± 1.3 55.0 ± 0.5 56.2 ± 1.3
  1. Statistical significance determined from one-way analysis of variance (ANOVA) followed by post hoc Newman-Keuls test. All data are expressed as means ± standard error of the mean. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. controls.
  2. BV: bone volume; TV: total volume; TbN: trabecular number; TbTh: trabecular thickness; TbSp: trabecular separation; ConnD: connectivity density; Bar: bone area: TtAr: total cross sectional area; MeAr: medullary area; CtTh: cortical thickness; BPm: bone perimeter; LY: LY303870.