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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Recurrent/moderate hypoglycemia induces hippocampal dendritic injury, microglial activation, and cognitive impairment in diabetic rats

Figure 1

Neuronal death in the cerebral cortex and hippocampus after severe or moderate hypoglycemia in diabetic rats. (A) In sham hypoglycemia-operated rats, neuronal death (FJB (+) neurons) was not detected in diabetic rats. In both diabetic and non-diabetic rats, recurrent/moderate (R/M) hypoglycemia shows only occasional neuronal death in the cerebral cortex while acute/severe (A/S) hypoglycemia shows widespread neuronal death in the superficial layer of cortex at 7 days after hypoglycemia. Bar = 100 μm. (B) Bar graph represents counted degenerating neurons in the cerebral cortex. Data are mean + s.e.m.; n = 5 in R/M hypoglycemia, n = 7 in A/S hypoglycemia * P < 0.05. (C) R/M hypoglycemia shows no neuronal death (FJB (+) neurons) in the hippocampal CA1 and DG cell layer while severe hypoglycemia shows substantial neuron death in the hippocampus at seven days after hypoglycemia. Bar = 100 μm. (D) Light microscopic images represent hematoxylin & eosin (H&E) stained hippocampus from CA1 and DG cell layer. R/M hypoglycemia shows no neuronal death (eosinophilic) in the hippocampal CA1 and DG cell layer while severe hypoglycemia shows substantial neuronal death in the hippocampus at seven days after hypoglycemia. Bar = 100 μm.

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