Repeated episodes of moderate hypoglycemia induce a significant increase in oxidative injury in the hippocampal CA1 dendritic area. (A) Fluorescent images show MAP2 (green) and 4HNE (red) antibody stained stratum radiatum (SR) of hippocampal CA1 area. The 4HNE intensity in the dendritic area after R/M hypoglycemia (R/M HG) is substantially increased. This 4HNE intensity increase is much higher in the diabetic rats, which suggests oxidative injury in the dendritic area of hippocampus is worse in the diabetic animal. SP, Stratum pyramidalae. Bar = 100 μm. (B) Bar graph represents quantitated 4HNE fluorescent intensity from the SR area of hippocampal CA1 area. Data are mean + s.e.m.; n = 7, * P < 0.05.