Effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculation in endotoxinemic rats

Table 1 Group averaged data for glucose, lactate, pH, pC02 and hemoglobin

	Glucose (mg/dl)		Lactate (mmol/l)		pH		p0₂(mmHg)		pC0₂(mmHg)		Hemoglobin (g/l)
	Baseline	End	Baseline	End	Baseline	End	Baseline	End	Baseline	End	Baseline	End
SHAM	63 ± 8	84 ± 21	0.8 ± 0.05	0.9 ± 0.1	7.49 ± 0.06	7.47 ± 0.03	250 ± 18	246 ± 29	36 ± 3	38 ± 4	140 ± 10	120 ± 20**
VGX	98 ± 30	98 ± 18	0.8 ± 0.03	0.9 ± 0.1	7.45 ± 0.05	7.50 ± 0.06	265 ± 19	250 ± 23	41 ± 8	33 ± 4	140 ± 10	130 ± 10*
VGX + STIM	71 ± 15	105 ± 49	0.9 ± 0.2	1.3 ± 0.5	7.52 ± 0.06	7.51 ± 0.04	259 ± 19	248 ± 5	37 ± 5	36 ± 5	130 ± 10	100 ± 20*
SHAM LPS	65 ± 13	69 ± 26	0.8 ± 0.1	1.9 ± 0.5^s	7.47 ± 0.05	7.45 ± 0.03	250 ± 14	233 ± 30	40 ± 4	35 ± 3*	150 ± 10	120 ± 10 ^s
VGX LPS	82 ± 22	129 ± 90	0.8 ± 0.1	2.2 ± 0.7^s	7.45 ± 0.07	7.37 ± 0.08**	272 ± 13	249 ± 26	41 ± 6	39 ± 4	150 ± 10	120 ± 20**
VGX LPS+ STIM	85 ± 25	65 ± 20	0.9 ± 0.1	1.8 ± 0.6***	7.48 ± 0.4	7.43 ± 0.1	251 ± 22	233 ± 21	38 ± 2	35 ± 5	130 ± 10	100 ± 20***

Data are given as the mean ± standard deviation (SD) together with statistical differences. Significance is given as: *, P < 0.05; **, P < 0.01; ***, P < 0.001; ^s, P < 0.0001 compared with baseline. LPS, lipopolysaccharide; pC0₂, partial pressure of carbon dioxide; SHAM, sham surgery; VGX, bilateral vagotomy; VGX + STIM, bilateral vagotomy and distal vagus nerve stimulation.

ISSN: 1742-2094