Baseline | 30 min | 60 min | 120 min | 180 min | 240 min | 270 min | ||
---|---|---|---|---|---|---|---|---|
Mean BP (mmHg) | SHAM | 116 ± 20 | 120 ± 12 | 108 ± 20 | 113 ± 14 | 114 ± 19 | 108 ± 20 | 108 ± 20 |
Mean BP (mmHg) | VGX | 115 ± 13 | 110 ± 13 | 112 ± 19 | 109 ± 14 | 110 ± 17 | 115 ± 22 | 115 ± 22 |
Mean BP (mmHg) | VGX + STIM | 109 ± 10 | 99 ± 14 | 103 ± 18 | 100 ± 23 | 104 ± 29 | 93 ± 21 | 93 ± 21 |
Mean BP (mmHg) | SHAM LPS | 123 ± 11 | 118 ± 14 | 106 ± 15** | 104 ± 10** | 90 ± 12s | 90 ± 18s | 90 ± 18s |
Mean BP (mmHg) | VGX LPS | 117 ± 9 | 109 ± 17 | 91 ± 17s | 94 ± 18*** | 101 ± 13* | 97 ± 10** | 97 ± 10** |
Mean BP (mmHg) | VGX LPS + STIM | 119 ± 13 | 114 ± 12 | 94 ± 17* | 92 ± 7*** | 86 ± 20 s | 90 ± 14*** | 90 ± 14*** |
SEP (μV) | SHAM | 13 ± 7 | 15 ± 6 | 14 ± 4 | 15 ± 5 | 14 ± 5 | 15 ± 5 | 14 ± 5 |
SEP (μV) | VGX | 15 ± 9 | 15 ± 8 | 16 ± 9 | 16 ± 9 | 15 ± 6 | 15 ± 6 | 16 ± 8 |
SEP (μV) | VGX + STIM | 15 ± 9 | 13 ± 4 | 14 ± 4 | 12 ± 5 | 11 ± 5 | 13 ± 3 | 15 ± 8 |
SEP (μV) | SHAM LPS | 17 ± 5 | 16 ± 6 | 15 ± 6 | 12 ± 6 | 11 ± 5 | 11 ± 4** | 10 ± 6** |
SEP (μV) | VGX LPS | 18 ± 6 | 15 ± 4 | 14 ± 5 | 12 ± 4** | 11 ± 7** | 10 ± 5** | 8 ± 5*** |
SEP (μV) | VGX LPS + STIM | 18 ± 8 | 18 ± 9 | 19 ± 9 | 16 ± 5 | 16 ± 5 | 14 ± 4 | 15 ± 7 |
P1 latency (ms) | SHAM | 10.8 ± 1 | 11.1 ± 1 | 11.2 ± 1 | 11.1 ± 1 | 11.3 ± 1 | 11.4 ± 1 | 11.7 ± 2 |
P1 latency (ms) | VGX | 10 ± 0.6 | 10 ± 0.5 | 10 ± 0.6 | 10 ± 0.4 | 10 ± 0.4 | 10 ± 0.4 | 10.1 ± 0.5 |
P1 latency (ms) | VGX + STIM | 10.2 ± 1 | 10.4 ± 1 | 10.5 ± 1 | 10.3 ± 1 | 10 ± 0.7 | 10 ± 0.7 | 10 ± 0.9 |
P1 latency (ms) | SHAM LPS | 10 ± 0.5 | 10 ± 0.6 | 10 ± 0.5 | 10 ± 0.6 | 10 ± 0.6 | 10.3 ± 0.7 | 10.4 ± 1 |
P1 latency (ms) | VGX LPS | 10 ± 0.8 | 10.4 ± 1 | 10.4 ± 0.8 | 10.6 ± 0.4 | 10.6 ± 0.7 | 11 ± 0.9 | 11 ± 1 |
P1 latency (ms) | VGX LPS + STIM | 10 ± 0.4 | 10 ± 0.3 | 10 ± 0.3 | 10 ± 0.3 | 10 ± 0.4 | 10.2 ± 0.4 | 10 ± 0.4 |
EFVR (%) | SHAM | 34 ± 10 | 26 ± 7 | 30 ± 11 | 31 ± 15 | 29 ± 14 | 31 ± 12 | 28 ± 7 |
EFVR (%) | VGX | 23 ± 13 | 23 ± 15 | 21 ± 11 | 24 ± 15 | 24 ± 6 | 23 ± 7 | 24 ± 11 |
EFVR (%) | VGX + STIM | 33 ± 13 | 35 ± 18 | 36 ± 13 | 29 ± 17 | 31 ± 18 | 32 ± 25 | 38 ± 14 |
EFVR (%) | SHAM LPS | 27 ± 11 | 29 ± 11 | 26 ± 8 | 18 ± 10 | 18 ± 16 | 14 ± 11* | 12 ± 8* |
EFVR (%) | VGX LPS | 34 ± 9 | 36 ± 7 | 26 ± 5 | 19 ± 9** | 17 ± 16** | 7 ± 5s | 7 ± 4s |
EFVR (%) | VGX LPS + STIM | 34 ± 8 | 35 ± 11 | 32 ± 9 | 31 ± 13 | 28 ± 12 | 29 ± 13 | 28 ± 13 |
Resting LDF (U) | SHAM | 163 ± 66 | 152 ± 71 | 140 ± 62 | 145 ± 82 | 142 ± 75 | 145 ± 71 | 139 ± 72 |
Resting LDF (U) | VGX | 233 ± 78 | 219 ± 106 | 211 ± 88 | 199 ± 84 | 203 ± 101 | 213 ± 111 | 201 ± 107 |
Resting LDF (U) | VGX + STIM | 224 ± 92 | 231 ± 75 | 232 ± 60 | 239 ± 30 | 193 ± 33 | 196 ± 49 | 186 ± 57 |
Resting LDF (U) | SHAM LPS | 202 ± 56 | 198 ± 64 | 186 ± 64 | 189 ± 72 | 204 ± 96 | 215 ± 104 | 250 ± 105 |
Resting LDF (U) | VGX LPS | 160 ± 70 | 141 ± 58 | 151 ± 62 | 157 ± 57 | 192 ± 60 | 198 ± 67 | 196 ± 59 |
Resting LDF (U) | VGX LPS + STIM | 173 ± 68 | 165 ± 69 | 177 ± 69 | 185 ± 65 | 227 ± 35 | 231 ± 56 | 227 ± 52 |