Analysis of DNA fragmentation detected in samples collected from the CA3 subfield of the hippocampus 7 days after microinjection of kainic acid (KA) (0.5 nmol) or PBS into the left hippocampal CA3 subfield in animals that received pretreatment with application into the bilateral CA3 subfield of 3% dimethyl sulfoxide (DMSO), 6 nmol rosiglitazone (RGZ) or 500 ng GW9662. (A) Qualitative analysis. (B) Quantitative analysis. Values in panel B are fold changes with reference to sham-control and are mean ± standard error of the mean (SEM) of four animals per experimental group. *P < 0.05 versus sham-control group, +P < 0.05 versus sham-control, DMSO + KA or GW9662 + KA group, and #P < 0.05 versus sham-control, DMSO + KA or RGZ + KA group in the Scheffé multiple-range test.