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Figure 1 | Journal of Neuroinflammation

Figure 1

From: CC chemokine ligand 2 upregulates the current density and expression of TRPV1 channels and Nav1.8 sodium channels in dorsal root ganglion neurons

Figure 1

CCL2 pretreatment augments capsaicin-evoked inward cationic currents in small-diameter dorsal root ganglion neurons. (A) Compared with capsaicin (0.3 μM)-induced inward cationic current in a control small dorsal root ganglion (DRG) sensory neuron, the amplitude of capsaicin-evoked inward current was greatly increased in a small-diameter DRG neuron preincubated with 5 nM chemokine CC chemokine ligand 2 (CCL2) for 24 hours. Holding potential (VH) = −60 mV. (B) CCL2 pretreatment increased the density of capsaicin (0.3 μM)-induced inward currents with a concentration-dependent manner. Each point shows the mean ± standard error value of 10 neurons.

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Journal of Neuroinflammation

ISSN: 1742-2094