Skip to main content
Figure 7 | Journal of Neuroinflammation

Figure 7

From: Toll-like receptor 2 deficiency leads to delayed exacerbation of ischemic injury

Figure 7

Reduced levels of Insulin-like growth factor 1 in brains of Toll-like receptor 2 deficient mice after stroke. (A) Photomicrographs of (IGF)-1 immunoreactivity in control (unlesioned) and lesioned brain hemispheres at 3 and 7 days after stroke, showing reduced levels of IGF-1 immunoreactivity in Toll-like receptor (TLR) 2−/− mice. (B) Quantification of signal intensity indicates a reduced level of IGF-1 present in the brains of TLR2−/− mice following transient ischemia compared with wild-type (WT) mice. (C, D) Double immunofluorescence labeling reveals that IGF-1 expression was present in microglia/macrophages within and around the infarcted region in both 3 and 7 days after ischemia. Data (B) are indicated as mean ± SEM (n = 4; *P <0.05, **P <0.001). Scale bars: A, 100 μm; C, D: 50 μm.

Back to article page