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Table 8 The factors associated with 1-year function outcome

From: Relationship between plasma high mobility group box-1 protein levels and clinical outcomes of aneurysmal subarachnoid hemorrhage

 

GOS 1 to 3

GOS 4 to 5

Pvalue

 

(n = 90)

(n = 213)

 

Sex (male/female)

42/48

89/124

0.433

Age (years)

44.7 ± 11.3

43.5 ± 12.8

0.422

WFNS score on admission

3.6 ± 0.7

1.8 ± 0.9

<0.001

Modified Fisher score on admission

3.8 ± 0.8

2.3 ± 0.7

<0.001

Aneurysmal location

  

0.291

 Posterior communication artery

24 (26.7%)

59 (27.7%)

 

 Internal carotid artery

13 (14.4%)

30 (14.1%)

 

 Anterior communication artery

17 (18.9%)

49 (23.0%)

 

 Middle cerebral artery

14 (15.6%)

31 (14.6%)

 

 Anterior cerebral artery

7 (7.8%)

28 (13.1%)

 

 Posterior cerebral artery

11 (12.2%)

12 (5.6%)

 

 Vertebral artery

4 (4.4%)

4 (1.9%)

 

Surgery

54 (60.0%)

132 (62.0%)

0.747

Aneurysmal size (mm)

10.4 ± 5.8

5.9 ± 3.7

<0.001

Rebleeding

10 (11.1%)

6 (2.8%)

0.003

Acute hydrocephalus

47 (52.2%)

43 (20.2%)

<0.001

Intracerebral hemorrhage

20 (22.2%)

19 (8.9%)

0.002

Intraventricular hemorrhage

59 (65.6%)

12 (5.6%)

<0.001

External ventricular drain

66 (73.3%)

43 (20.2%)

<0.001

Angiographic vasospasm

71 (78.9%)

60 (28.2%)

<0.001

Computed tomography ischemia

28 (31.1%)

22 (10.3%)

<0.001

Admission time (hours)

4.5 ± 3.5

4.8 ± 3.7

0.577

Seizure

19 (21.1%)

25 (11.7%)

0.085

Plasma C-reactive protein level (mg/L)

8.2 ± 3.2

6.7 ± 2.4

<0.001

plasma D-dimer level (mg/L)

2.4 ± 1.2

1.9 ± 0.9

<0.001

Plasma HMGB1 level (ng/mL)

11.5 ± 3.1

7.3 ± 3.0

<0.001

  1. Numerical variables are presented as mean ± standard deviation. Categorical variables are expressed as counts (percentage). Numerical variables were analyzed by Mann–Whitney U-test or unpaired Student t test. Categorical variables were analyzed by chi-square test or Fisher exact test. GOS, Glasgow Outcome Scale; HMGB1, high mobility group box-1; n, number of patients; WFNS, World Federation of Neurological Surgeons.