Figure 6

Schematic representing requirements for primary phagocytosis of neurons to proceed. Primary phagocytosis of viable neurons does not proceed without microglial activation. Basal levels of surface-exposed CRT are not sufficient alone to allow phagocytosis, but CRT-dependent phagocytosis can be triggered by an increase in either PS or CRT exposure. CRT, calreticulin; PS, phosphatidylserine.