Figure 5

Increases in the levels of IL-1β and TNF-α mRNAs following LPS (i.p.) injection and suppression by Pls in the murine PFC and hippocampus. A, Significant increases in the levels of IL-1β (left) and TNF-α (right) mRNAs in the PFC were seen in the LPS group compared with that observed in the other groups (Con, LPS + Pls and Pls groups). B, Significant increases in the levels of IL-1β (left) and TNF-α (right) mRNAs in the hippocampus were seen in the LPS group compared to that observed in the other groups. Each bar, n = 5, **, P <0.01. _Con, control; IL-1β, interleukin-1β; i.p., intraperitoneal; LPS, lipopolysaccharide; PFC, prefrontal cortex; Pls, plasmalogens; TNF-α, tumor necrosis factor α.