Anti-inflammatory/anti-amyloidogenic effects of plasmalogens in lipopolysaccharide-induced neuroinflammation in adult mice

Table 2 The changes in the phospholipid levels in the PFC and hippocampus following LPS and Pl injection

	Con	LPS	LPS + Pls	Pls
1) PFC
PlsEtn	16.40 ± 0.59	13.41 ± 0.73*	16.29 ± 0.53	17.81 ± 0.32
PEtn	21.92 ± 0.63	22.66 ± 0.65	22.48 ± 0.26	22.65 ± 0.22
PlsCho	0.20 ± 0.03	0.19 ± 0.03	0.21 ± 0.03	0.28 ± 0.04
PCho	44.04 ± 1.12	47.73 ± 1.04	43.73 ± 0.97	46.74 ± 0.85
SM	3.72 ± 0.20	3.13 ± 0.31	3.47 ± 0.24	3.31 ± 0.15
PS	11.88 ± 0.27	11.08 ± 0.30	12.03 ± 0.22	10.58 ± 0.56
PI	1.86 ± 0.12	1.80 ± 0.07	1.87 ± 0.21	1.64 ± 0.31
PlsEtn/PEtn ratio	0.75 ± 0.02	0.59 ± 0.03*	0.73 ± 0.03	0.79 ± 0.01
2) Hippocampus
PlsEtn	24.18 ± 0.64	20.29 ± 0.31*	22.88 ± 0.45	22.68 ± 0.39
PEtn	20.38 ± 0.43	22.07 ± 0.62	20.21 ± 0.41	20.80 ± 0.57
PlsCho	0.49 ± 0.06	0.42 ± 0.04	0.45 ± 0.05	0.41 ± 0.03
PCho	36.90 ± 1.74	39.39 ± 0.38	37.64 ± 1.37	39.90 ± 1.04
SM	5.24 ± 0.67	5.36 ± 0.59	5.71 ± 0.64	4.13 ± 0.68
PS	11.73 ± 0.86	10.94 ± 0.25	11.71 ± 0.61	10.59 ± 0.34
PI	1.59 ± 0.10	1.63 ± 0.16	1.72 ± 0.06	1.48 ± 0.16
PlsEtn/PEtn ratio	1.19 ± 0.05	0.92 ± 0.03*	1.14 ± 0.04	1.09 ± 0.05

The values are expressed as the mean ± SEM (n = 5) of the % level of the phospholipids, except for the last row. *, P <0.05 compared to the Con group (Steel test for multiple comparisons). Con, control; PCho, phosphatidyl choline; PEtn, phosphatidyl ethanolamine; PFS, prefrontal cortex; LPS, lipopolysaccharide; PI, phosphatidyl inositol; Pl, plasmalogen; PlsCho, choline plasmalogen; PlsEtn, ethanolamine plasmalogen; PS, phosphatidyl serine; SEM, standard error of the mean; SM, sphingomyelin.

ISSN: 1742-2094