Figure 5From: Hydrogen sulfide attenuates spatial memory impairment and hippocampal neuroinflammation in beta-amyloid rat model of Alzheimer’s disease Effect of NaHS on the IL-1β, TNF-α production, and mRNA expressions. IL-1β and TNF-α levels in the hippocampus were measured via ELISA. The expressions of IL-1β and TNF-α mRNA in the hippocampus were detected by real time RT-PCR. Aβ1-40 injection into the hippocampus significantly increased the IL-1β, TNF-α production, and mRNA expressions. Treatments with NaHS significantly decreased the levels and mRNA over-expressions of IL-1β and TNF-α. (A) The level of IL-1β. (B) The level of TNF-α. (C) The expressions of IL-1β mRNA. (D) The expressions of TNF-α mRNA. Data are mean ± S.E.M., n = 4. **P < 0.01 vs. sham; ## P < 0.01, # P < 0.05 vs. Aβ1-40. Back to article page