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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Protein expression profiling of inflammatory mediators in human temporal lobe epilepsy reveals co-activation of multiple chemokines and cytokines

Figure 6

Correlation network plots for all patient groups. Network plots depicting significant correlations between levels of inflammatory mediators in Control patients (A), mTLE -HS patients (B) and mTLE + HS patients (C). Line (edge) color indicates in which tissue correlation was found: red = HC, blue = CX, green = HC & CX. Per patient group two main non-overlapping correlation networks were identified. Note that correlation networks are remarkably similar among the patient groups. Inflammatory mediators like IL-5, IL-13 and IL-22 all display >4 correlations with other inflammatory mediators. Only proteins that were in a network of more than 6 correlations (nodes) are depicted. In addition, 5 significant correlations were found in the total data set. In Control HC IL-10 & CCL3 correlated with IL-25 and in mTLE-HS CX Cathepsin-S correlated with ICAM1. All correlations had a correlation coefficient > 0.85 with a Bonferoni corrected p-value < 0.0017

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