Journal of Neuroinflammation

Table 5 Summary principle component analysis

From: Protein expression profiling of inflammatory mediators in human temporal lobe epilepsy reveals co-activation of multiple chemokines and cytokines

A
Component-HC
1	2	3	4	5	6	7	8
37.7%	13.4%	11.1%	7.5%	6.7%	5.3%	3.7%	3.2%
IL-13	CCL4	CCL3	IL-6R	TIMP1	CCL19	TNFα	IL-23
IL-5	CCL2	IL-10	IL-18	IL-6	CCL5*	IL-1RA	CCL18
IL-22	IL-1α	ICAM1	Adiponectin	Cathepsin-S	IL-1β *	IL-4
CCL19	IL-8	IL-27	IL-1β		MIF
VEGF	CCL3	IL-25
CCL22	CCL5	IL-21
CXCL9		IFNα
VCAM1		IL-6R
IL-7
HGF
IL-23
mTLE Δ	mTLE Δ	mTLE + HS Δ	ND	ND	mTLE + HS Δ	ND	ND
control	control	-HS & control			& control
B
Component-CX
1	2	3	4	5	6	7	8
40.1%	10%	8.4%	8%	5.8%	5%	4%	3.3%
IL-5	IL-18	CCL2	Adiponectin	CXCL9	TIMP1	IL-1β	IL-25
VEGF	IL-6R	CCL4	ICAM1	CCL5	CXCL8.IL-8	IL-6	IL-21
VCAM1	MIF	Adiponectin	Cathepsin-S	HGF	IL-1α	IFNα	IL-4
CCL3	IL-1β	CXCL8.IL-8	CCL18		TNFα	IL-23	IL-10
CCL19	TNFα				IL-4
IL-1RA
IL-27
IL-22
IL-13
IL-25
CCL22
IL-7
CXCL9
IL-1α
IL-23
TNFα
mTLE Δ	ND	ND	ND	mTLE Δ	mTLE + HS Δ	ND	mTLE + HS Δ
control				control	& control		-HS & control

PCA identified 8 components in HC(A) and CX (B) that explain 88.5% (HC) and 84% (CX) of the variance in all the samples. The contribution of each component to the variance is given as percentage. Inflammatory mediators are listed in order of factor loading. Under each component list significant differences in this component between patient groups is indicated (delta). ND = no difference detected between component scores among the three patient groups.

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ISSN: 1742-2094

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