Figure 1From: Neuronal c-Abl activation leads to induction of cell cycle and interferon signaling pathways Cell cycle activation in the AblPP/tTA mouse. Western blotting of wild-type versus AblPP/tTA mouse forebrain homogenates. Cyclin B1 and Cdk4 levels are elevated in mice expressing consitutively active c-Abl for 2 weeks, but not 4 weeks, consistent with increased mRNA levels (Table 3). Polo-like kinase (PLK1) levels were elevated at 2 and 4 weeks, but mRNA levels were only elevated at 2 weeks.Back to article page