Figure 5
From: Neuronal c-Abl activation leads to induction of cell cycle and interferon signaling pathways
STAT1 expression occurs in neurons of the CA1 region of the hippocampus in AblPP/tTA mice prior to neuronal loss. (A-E) STAT1 immunohistochemistry of the CA1 region of an AblPP/tTA mouse expressing constitutively active c-Abl for 3 weeks (B,D,E) versus wild-type control (A,C). (F,G) STAT1pY701 immunohistochemistry the CA1 region of a wild-type mouse (F) versus an AblPP/tTA mouse 3 weeks off doxycyline (G). Cells positive for STAT1 pY701 are indicated with arrows. (H,I) Double labeling with NeuN (green) and total STAT1 (red) in wild-type (panel H) and AblPP mice expressing constitutively active c-Abl for 2 weeks (panel I). Scalebars: A,B = 2 mm; C,D,F,G = 800 μm; E = 400 μm.