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Table 1 Previous studies relating IL-6 polymorphisms to AD risk

From: Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease

Reference

Population

(AD:control)

SNP (w.t./variant)a

Haplotype (SNP)

Results

Limitations

Arosio et al.

Neurobiol. Aging 2004, 25:1009-15 [9]

Italian

(65:65)

rs1800795 (G/C)

No significant association

Italian only

One SNP only

Small sample size

Licastro et al.

Neurobiol. Aging

2003, 24:921-26 [8]

Italian

(332:393)

rs1800795 (G/C)

rs1800795:

CC vs. GG: OR = 1.62, 95% CI = 1.20-2.17

Italian only

One SNP only

Depboylu et al.

Geriatr. Cogn. Disord

2004, 17:170-73 [10]

German

(113:108)

rs1800795 (G/C)

No significant association

German only

One SNP only

van Oijen et al.

Neurosci. Lett.

2006, 402:113-17 [11]

Netherlander

(483:5636)

rs1800795 (G/C)

No significant association

Netherlanders only

One SNP only

He et al.

Neurol. Sci.

2010, 31:165-8 [12]

Chinese

(318:324)

rs1800796 (C/G)

rs13447446 (G/C)

rs1800796:

GG vs. CC: OR = 0.42, 95% CI = 0.20-0.89

Chinese only

Not applicable for rs13447446 (No GC or CC variants)

Wang et al.

Neurosci. Lett.

2010, 482:260-3 [13]

Chinese

(341:421)

rs1800796 (C/G)

rs7802308 (A/T)

haplotype rs1800796/rs7802308

rs1800796 (in ApoE e4 carrier):

1) CC vs. CG + GG: OR = 3.3,

95% CI = 1.64-6.67

2) A risk haplotype (CA) (OR = 2.24)

3) A protective haplotype (GA) (OR = 0.41)

Chinese only

Significant only in ApoE e4-carrier

rs7802308 is a rare SNP for analysis

Nishimura et al.

Neurosci. Lett.

2004, 368:140-3 [14]

Japanese

(172:163)

rs1800796 (C/G)

No significant association

Japanese only

One SNP only

  1. a Words underlined indicates SNPs genotyped in our study.
  2. Abbreviations: OR, odds ratio; AD, Alzheimer's disease; SNP, single nucleotide polymorphism; w.t., wild type.