Reference | Population (AD:control) | SNP (w.t./variant)a Haplotype (SNP) | Results | Limitations |
---|---|---|---|---|
Arosio et al. Neurobiol. Aging 2004, 25:1009-15 [9] | Italian (65:65) | rs1800795 (G/C) | No significant association | ◈Italian only ◈One SNP only ◈Small sample size |
Licastro et al. Neurobiol. Aging 2003, 24:921-26 [8] | Italian (332:393) | rs1800795 (G/C) | rs1800795: CC vs. GG: OR = 1.62, 95% CI = 1.20-2.17 | ◈Italian only ◈One SNP only |
Depboylu et al. Geriatr. Cogn. Disord 2004, 17:170-73 [10] | German (113:108) | rs1800795 (G/C) | No significant association | ◈German only ◈One SNP only |
van Oijen et al. Neurosci. Lett. 2006, 402:113-17 [11] | Netherlander (483:5636) | rs1800795 (G/C) | No significant association | ◈Netherlanders only ◈One SNP only |
He et al. Neurol. Sci. 2010, 31:165-8 [12] | Chinese (318:324) | rs1800796 (C/G) rs13447446 (G/C) | rs1800796: GG vs. CC: OR = 0.42, 95% CI = 0.20-0.89 | ◈Chinese only ◈Not applicable for rs13447446 (No GC or CC variants) |
Wang et al. Neurosci. Lett. 2010, 482:260-3 [13] | Chinese (341:421) | rs1800796 (C/G) rs7802308 (A/T) haplotype rs1800796/rs7802308 | rs1800796 (in ApoE e4 carrier): 1) CC vs. CG + GG: OR = 3.3, 95% CI = 1.64-6.67 2) A risk haplotype (CA) (OR = 2.24) 3) A protective haplotype (GA) (OR = 0.41) | ◈Chinese only ◈Significant only in ApoE e4-carrier ◈rs7802308 is a rare SNP for analysis |
Nishimura et al. Neurosci. Lett. 2004, 368:140-3 [14] | Japanese (172:163) | rs1800796 (C/G) | No significant association | ◈Japanese only ◈One SNP only |