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Table 3 Characteristics of IL-6 haplotype-tagging SNPs and ApoE SNPs

From: Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease

    

HapMap or dbSNP

This study

SNP name

Nucleotide change

Location

rs no.

MAF

Controls

Cases

    

CEU

JPT

CHB

MAF

HWE

MAF

HWE

        

χ 2

p

 

χ 2

p

SNP1

C→G

Promoter

rs1800796

0.04

0.14

0.23

0.26

0.98

0.32

0.22

0.36

0.55

SNP2

A→G

Intron

rs2069837

0.08

0.10

0.17

0.19

2.59

0.11

0.16

0.04

0.84

SNP3

T→C

Intron

rs1524107

0.05

0.18

0.29

0.27

1.31

0.25

0.22

0.22

0.64

ApoE112

T→C

Exon

rs429358

0.15*

0.01

0.00

0.08

0.17

0.68

0.23

1.24

0.27

ApoE158

C→T

Exon

rs7412

0.08*

0.05

0.11

0.08

1.49

0.22

0.06

0.001

0.97

  1. Abbreviations: CEU, Utah residents with Northern and Western European ancestry from the CEPH collection; JPT, Japanese in Tokyo, Japan; CHB, Han Chinese in Beijing; HWE p, p value for Hardy-Weinberg equilibrium test; MAF, minor allele frequency; SNP, single nucleotide polymorphism.
  2. The degree of freedom is 1 for all HWE tests.
  3. * MAF data were obtained from dbSNP because the data was not available from the HapMap Project.