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Table 4 Association between IL-6 SNPs and LOAD risk by ApoE e4 status

From: Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease

Dominant model

Additive model

 

0 copies

1 or 2 copies

  
 

Case/

control

AOR

Case/

control

AOR (95% CI)

p

AOR (95% CI)

p

SNP1

162/245

1.00

104/196

0.64 (0.43-0.94)*

0.02

0.67 (0.50-0.91)*

0.01

ApoE e4 non-carriers

100/207

1.00

61/166

0.56 (0.35-0.90)*

0.02

0.61 (0.42-0.90)*

0.01

ApoE e4 carriers

61/37

1.00

43/29

0.82 (0.40-1.70)

0.60

0.81 (0.49-1.34)

0.28

SNP2

180/293

1.00

75/141

0.78 (0.51-1.19)

0.25

0.80 (0.56-1.14)

0.21

ApoE e4 non-carriers

114/249

1.00

40/118

0.72 (0.43-1.20)

0.21

0.72 (0.46-1.12)

0.14

ApoE e4 carriers

66/43

1.00

35/22

0.89 (0.42-1.91)

0.77

0.99 (0.54-1.83)

0.59

SNP3

163/242

1.00

102/199

0.60 (0.41-0.89)*

0.01

0.66 (0.49-0.90)*

< 0.01

ApoE e4 non-carriers

101/204

1.00

60/169

0.55 (0.35-0.88)*

0.01

0.60 (0.41-0.89)*

0.01

ApoE e4 carriers

61/37

1.00

42/29

0.73 (0.36-1.52)

0.40

0.81 (0.48-1.34)

0.23

  1. All models were adjusted for age, gender, education, and ApoE e4 status.
  2. Abbreviations: AOR, adjusted odds ratio; LOAD, late-onset Alzheimer's disease; SNP, single nucleotide polymorphism.
  3. * p value remained significant after controlling for type I error by using FDR.