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Table 7 Association between IL-6 haplotype CAT and LOAD by hypertension or type 2 DM

From: Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease

 

2 copiesa

0 or 1 copy

p interaction b

 

Case/Control

AOR

Case/Control

AOR (95% CI)

 

Hypertension

     

   No

94/104

1.00

71/100

0.67 (0.39-1.15)

0.49

   Yes

65/139

1.00

36/100

0.52 (0.29-0.95)

 

Type 2 DM

     

   No

133/209

1.00

84/171

0.59 (0.39-0.92)

0.36

   Yes

25/33

1.00

23/29

0.91 (0.36-2.26)

 
  1. Abbreviation: AOR, adjusted odds ratio; DM, diabetes mellitus; LOAD, late-onset Alzheimer's disease.
  2. All models were adjusted for age, gender, education, and ApoE e4 status.
  3. a 2 copies of haplotype CAT was used as the reference group because it is a major haplotype.
  4. b p interaction value was obtained by using the dominant model.
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Journal of Neuroinflammation

ISSN: 1742-2094