Figure 1 From: Neuroinflammation and oxidative stress in rostral ventrolateral medulla contribute to neurogenic hypertension induced by systemic inflammation Infusion of LPS into the peritoneal cavity elevates blood pressure and plasma level of pro-inflammatory cytokines. Time-course changes in mean SAP (MSAP) (A), HR (B), or plasma level of CRP (C), TNF-α (D), and IL-1β (E), measured on days 7 or 14 after intraperitoneal infusion of saline or LPS (1.2 mg/kg/day) via an osmotic minipump for 14 days, alone or with additional intracisternal infusion of NS398 (1.5 nmol/μL/h). Values are mean ± SEM (n=8 to 10 animals in each experimental group). *P <0.05 vs. saline-treatment group at corresponding time-intervals or sham-control group; # P <0.05 vs. LPS-treatment group at corresponding time-intervals in the post hoc Scheffé multiple-range test. Arrow indicates the time point during which the osmotic minipump was implanted into the peritoneal cavity.Back to article page