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Figure 8 | Journal of Neuroinflammation

Figure 8

From: Neuroinflammation and oxidative stress in rostral ventrolateral medulla contribute to neurogenic hypertension induced by systemic inflammation

Figure 8

Intraperitoneal infusion of LPS downregulates Kv4.3 potassium channel in RVLM and increase the sympathetic neurogenic vasomotor activity. Representative gels (inset) and densitometric analysis of results from Western blot showing changes in expression of Kv4.3 channel protein in RVLM (A) or changes in the power density of the low frequency component of SAP spectrum (B), measured on day 7 after intraperitoneal infusion of saline or LPS (1.2 mg/kg/day), alone or with additional intracisternal infusion of minocycline (9 nmol/μL/h), NS398 (1.5 nmol/μL/h), PTX (30 nmol/μL/h), or tempol (1 μmol/μL/h). Values are mean ± SEM (n=8 to 10 animals in each experimental group). *P <0.05 vs. saline-treatment group; # P <0.05 vs. LPS-treatment group in the post hoc Scheffé multiple-range test

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