Impact of treatments on B1R agonist-induced increased rectal temperature. B1R agonist (SDABK, 1 mg/kg) was injected intraperitoneally in STZ rats pre-treated (2 h earlier) either with vehicle or inhibitors of COX-1 (indomethacin, 10 mg/kg, i.p.), COX-2 (niflumic acid, 15 mg/kg, i.p.) or NOS (L-NAME, 30 mg/kg, i.p.). B1R agonist-induced hyperthermia was also evaluated in STZ rats subjected to subdiaphragmatic vagal nerve ligation (14 days earlier). Statistical comparison with STZ + SDABK pretreated with vehicle (*) is indicated by *** P <0.001. n = 4 to 7 rats.