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Table 3 Cytokine expression in cerebrospinal fluid cells and peripheral blood mononuclear cells

From: Cellular sources of dysregulated cytokines in relapsing-remitting multiple sclerosis

  

RRMS relapse

NIND

RRMS relapse vs NIND

 

Mean CT value

N

Median (IQR)

CSF/PBMC p-value

N

Median (IQR)

CSF/PBMC p-value

p-value

q-value

IFNG PBMC NR

32.3

15

4.10 (2.74 to 10.21)

 

10

5.25 (2.65 to 9.12)

 

0.78

0.37

IFNG CSF NR

34.9

15

7.22 (0.00 to 16.42)

 

10

0.00 (0.00 to 0.00)

 

0.004

0.02

IFNG CSF/PBMC Ratio

 

15

0.71 (0.00 to 2.31)

0.87

10

0.00 (0.00 to 0.00)

 

0.004

0.02

IL1B PBMC NR

32.4

16

1.13 (0.88 to 2.14)

 

10

1.81 (1.05 to 2.70)

 

0.19

0.15

IL1B CSF NR

36.7

14

0.21 (0.00 to 1.09)

 

10

2.70 (0.00 to 6.94)

 

0.36

0.23

IL1B CSF/PBMC Ratio

 

13

0.18 (0.00 to 0.92)

0.02

10

1.96 (0.00 to 6.40)

0.29

0.42

0.24

IL7 PBMC NR

34.0

16

0.41 (0.21 to 1.17)

 

10

0.31 (0.18 to 0.46)

 

0.40

0.24

IL7 CSF NR

36.1

13

0.00 (0.00 to 0.86)

 

10

0.00 (0.00 to 0.00)

 

0.06

0.09

IL7 CSF/PBMC Ratio

 

12

0.00 (0.00 to 2.51)

 

8

0.00 (0.00-0.00)

 

0.08

0.09

IL10 PBMC NR

34.3

16

2.75 (2.02 to 3.90)

 

10

2.95 (2.38 to 4.26)

 

0.54

0.27

IL10 CSF NR

35.3

17

23.51 (3.22 to 46.39)

 

10

116.78 (72.22 to 156.28)

 

0.001

0.01

IL10 CSF/PBMC Ratio

 

16

8.57 (0.79 to 12.71)

0.003

10

42.21 (24.04 to 66.18)

0.01

0.002

0.01

IL12A PBMC NR

37.5

16

0.49 (0.30 to 0.66)

 

10

0.54 (0.42 to 0.82)

 

0.53

0.27

IL12A CSF NR

38.3

15

0.00 (0.00 to 0.00)

 

10

0.00 (0.00 to 0.00)

 

0.24

0.17

IL12A CSF/PBMC Ratio

 

12

0.00 (0.00 to 0.00)

 

9

0.00 (0.00 to 0.00)

 

0.21

0.16

IL15 PBMC NR

36.3

16

1.19 (0.91 to 1.43)

 

10

1.10 (0.57 to 1.60)

 

0.79

0.37

IL15 CSF NR

37.3

14

0.00 (0.00 to 1.10)

 

10

0.00 (0.00 to 0.00)

 

0.07

0.09

IL15 CSF/PBMC Ratio

 

13

0.00 (0.00 to 0.97)

 

10

0.00 (0.00 to 0.00)

 

0.06

0.09

IL23 PBMC NR

34.6

16

0.80 (0.65 to 1.18)

 

10

0.80 (0.62 to 1.15)

 

1.00

0.44

IL23 CSF NR

36.8

14

1.12 (0.00 to 1.98)

 

10

0.00 (0.00 to 0.48)

 

0.10

0.10

IL23 CSF/PBMC Ratio

 

13

1.54 (0.00 to 3.17)

0.28

10

0.00 (0.00 to 1.50)

 

0.09

0.10

IL27 PBMC NR

35.1

16

4.74 (2.49 to 7.60)

 

10

8.36 (6.17 to 12.70)

 

0.045

0.09

IL27 CSF NR

ND

14

0.00 (0.00 to 0.00)

 

10

0.00 (0.00 to 0.00)

 

1.00

0.44

IL27 CSF/PBMC Ratio

 

12

0.00 (0.00 to 0.00)

 

10

0.00 (0.00 to 0.00)

 

1.00

0.44

LTA PBMC NR

34.3

16

1.74 (1.43 to 2.30)

 

10

2.11 (1.59 to 2.73)

 

0.37

0.23

LTA CSF NR

36.7

14

1.41 (0.00 to 3.20)

 

10

0.00 (0.00 to 0.00)

 

0.05

0.09

LTA CSF/PBMC Ratio

 

13

1.08 (0.00 to 1.82)

0.92

10

0.00 (0.00 to 0.00)

 

0.04

0.09

LTB PBMC NR

28.2

16

4.09 (2.44 to 4.99)

 

10

3.71 (3.06 to 5.54)

 

0.79

0.37

LTB CSF NR

33.5

13

8.05 (6.62 to 13.37)

 

10

8.82 (3.30 to 12.27)

 

0.42

0.23

LTB CSF/PBMC Ratio

 

12

2.37 (1.76 to 3.12)

0.002

10

1.70 (0.97 to 3.12)

0.04

0.13

0.11

  1. Gene expression data are shown as the normalization ratio (NR). Mean cycle threshold (CT) is shown for each target. CSF/PBMC ratio represent fold change in expression between CSF cells and PBMCs. CSF/PBMC P-values represents Wilcoxon signed rank test results, and tests were only conducted if median CSF NR was >0. All other P-values represent Mann–Whitney tests for differences between groups, and q-values represent false discovery rate corrected P-values. Significant test-values are in bold. CSF, cerebrospinal fluid; IQR, Interquartile range; NIND, non-inflammatory neurological disease; PBMC; peripheral blood mononuclear cell; RRMS relapse, relapsing-remitting multiple sclerosis patients in relapse.
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Journal of Neuroinflammation

ISSN: 1742-2094